The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Shocking Moments at the Olympics: Athlete Scores Zero in Diving
There are usually moments of success and disappointment during the Olympics. This year is no exception, with competitors vying for gold hailing from all across the world. But some sportsmen are more unfortunate than others in their circumstances. In one such instance, an Olympic diver’s perfect score startled onlookers.
Olympic women’s 3m springboard diver Alison Gibson of Team USA produced a devastating performance in the preliminary round. Her feet collided with the springboard on her debut dive, resulting in an agonizing error that left the spectators in shock. Sadly, the impact damaged her form, and she placed last among the 28 participants. She was disappointed to learn that she received a score of 0.0 for the dive from the judges.
Later on, Alison talked about the discomfort she felt during the dive. She’s still determined to keep doing what she loves in spite of the setback. She wants everyone witnessing to understand the perseverance required to move forward even when things don’t go according to plan. Alison thinks that every experience can be used to grow and learn, and she wants the athletes of the future to know that they can persevere bravely through difficult times.
These kinds of situations serve as a reminder of the highs and lows of the Olympic Games. In addition to applauding the wins and celebrating the successes, we should recognize the tenacity and will displayed by sportspeople like Alison Gibson. Their experiences encourage us to persevere and never give up in the face of difficulties.
Now let’s examine a few more noteworthy Olympic moments:
Yusuf Dikec of Turkey Wins Silver Medal “Without Equipment”
Turkish athlete Yusuf Dikec approached his sport in a unique way. During his event, he was seen appearing quite at ease, with one hand in his pocket and no shooting gear on. His relaxed approach paid off, and he and his partner unexpectedly took home the silver medal.
With a 100-meter personal best, Noah Lyles
American sprinter Noah Lyles won the 100-meter event with amazing style. He won by a mere 0.005 seconds, setting a new personal best time of 9.784 seconds. Taking less than ten seconds for all eight competitors to reach the finish line made this race the fastest-ever competition.
A chaotic 5000-meter race
During the 5000m race, a number of competitors staggered and fell face down onto the track, causing mayhem. Hugo Hay, a French runner, and George Mills of Team GB were among them. After the event, Mills had some harsh words to say to Hay, demonstrating the players’ intensity and rivalry.
Unforgettable Moment with Snoop Dogg
When Snoop Dogg arrived at the Grand Prix Special dressage team at the Olympics wearing breeches, a dressage tailcoat, and a hard hat, he made an impression. His distinct appearance and mannerisms gave the occasion a dash of excitement and fun.
These are only a handful of the many remarkable moments from the Olympics this year. We see amazing tales of tenacity and devotion from the Games, from unexpected triumphs to unanticipated obstacles. With their zeal, the athletes motivate us and serve as a constant reminder that anything is achievable with willpower and perseverance.
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