The grandma took the carrot out of the pot after a while and asked her granddaughter to explain what had happened to it. The granddaughter said that the carrot had become softer due to the heating water. The sage woman nodded before going on to the following pot.
She then removed the egg and asked about its metamorphosis. The granddaughter retorted that the hot water had solidified the egg. After considering her granddaughter’s observations, the grandma nodded once more.
The wise woman finally looked at the pot of coffee beans. She requested her granddaughter to tell her thoughts about the water that the coffee beans had been submerged in and the coffee beans themselves. The granddaughter retorted that the water had been transformed by the coffee beans, giving it a fresh flavor and scent.
The grandmother thoughtfully asked her granddaughter which of the three things—the carrot, the egg, or the coffee beans—she thought she looked most like.
After giving the topic some thought, the young woman understood the deep lesson her grandmother’s straightforward yet poignant illustration held. She realized that, similar to how boiling water shapes an egg and a carrot, life’s challenges may mold us in various ways.
When faced with hardship, the carrot, which is initially tough and stubborn, softens and becomes malleable. In a similar vein, when faced with hardship, the egg hardens with its protective shell. But the coffee beans, the epitome of tenacity and willpower, have the ability to change their situation and give them courage and optimism.
The granddaughter was very affected by this moving story. It reminded her that she had options when faced with obstacles in life. Adversity might either harden her and rob her of her fragility, like the egg, or it may make her weak and pliable, like the carrot. Alternatively, she may take a cue from the coffee beans and use her inner fortitude and fortitude to change the course of events and reach new heights for herself.
Which one then are you? Which are you, the coffee bean, the egg, or the carrot? Never forget that every obstacle presents a chance for development, transformation, and perseverance. Accept the lesson from this story and strive to be the coffee bean that rises above hardship, motivating others in the process.
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We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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